Title:
CYCLOHEXANE DERIVATIVE
Document Type and Number:
Japanese Patent JP2002201168
Kind Code:
A
Abstract:
To provide a new compound which exhibits a VLA-4 antagonist action in an excellent dynamic state in a living body or its salt, and to provide a medicine containing the compound as an active ingredient.
A cyclohexane derivative represented by the general formula (I) (R1 and R2 are each H, an alkyl, or the like; X is O, NH or the like; A is CO or SO2; R3 is a hydrocarbon group, a heterogeneous aryl group, a heterogeneous arylalkyl group, or the like; R4 is a hydrocarbon group, a heterogeneous aryl group, a heterogeneous arylalkyl group, a pyrrolidine ring-containing group, or the like) or its salt, and a medicine or VLA-4 antagonist containing the cyclohexane derivative or its salt as an active ingredient, are provided.
Inventors:
SHIMANO MASANAO
MATSUO ATSUSHI
HARADA TATSUHIRO
OKUDA TOSHIAKI
MATSUMURA YUZURU
MATSUO ATSUSHI
HARADA TATSUHIRO
OKUDA TOSHIAKI
MATSUMURA YUZURU
Application Number:
JP2000401521A
Publication Date:
July 16, 2002
Filing Date:
December 28, 2000
Export Citation:
Assignee:
KAKEN PHARMA CO LTD
International Classes:
C07D317/68; A61K31/198; A61K31/216; A61K31/357; A61K31/36; A61K31/40; A61K31/4025; A61K31/426; A61K31/4409; A61K31/4427; A61K31/443; A61K31/4439; A61K38/00; A61P29/00; A61P43/00; C07C229/14; C07C233/86; C07C271/22; C07C311/19; C07D207/16; C07D213/79; C07D277/06; C07D401/12; C07D405/12; C07D417/12; C07K5/06; (IPC1-7): C07C233/86; A61K31/198; A61K31/216; A61K31/36; A61K31/40; A61K31/4025; A61K31/426; A61K31/4409; A61K31/4439; A61K38/00; A61P29/00; A61P43/00; C07C229/14; C07C271/22; C07C311/19; C07D207/16; C07D213/79; C07D277/06; C07D317/68; C07D401/12; C07D405/12; C07D417/12; C07K5/06
Domestic Patent References:
| JP2003506491A | 2003-02-18 | |||
| JPH0399047A | 1991-04-24 | |||
| JPH03501969A | 1991-05-09 | |||
| JPS60109600A | 1985-06-15 |
Foreign References:
| WO1999015136A1 | 1999-04-01 | |||
| WO2000043354A2 | 2000-07-27 |
Attorney, Agent or Firm:
Nakamura Shizuo