Title:
シクロヘキシル(アルキル)プロパノールアミン、製造方法ならびにそれを含む医薬組成物
Document Type and Number:
Japanese Patent JP4024149
Kind Code:
B2
Abstract:
The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —SO2NH(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a —CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1-C4)alkyl group, an —SO2phenyl-(C1-C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a —COO(C1-C4)alkyl group, a —CO(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl groups, —NO2, —CN, —CONR4R5, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.
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Inventors:
Bovi, Philip, Elle.
Setch, Robert
Kurtmansh, Jill
Oliva, Ambrosio
Viviani, Nunzia
Kuroshi, Chiziano
Setch, Robert
Kurtmansh, Jill
Oliva, Ambrosio
Viviani, Nunzia
Kuroshi, Chiziano
Application Number:
JP2002546509A
Publication Date:
December 19, 2007
Filing Date:
November 30, 2001
Export Citation:
Assignee:
Sanofi-Aventis
International Classes:
C07C311/08; C07D295/18; A61K31/18; A61K31/235; A61K31/40; A61K31/421; A61K31/423; A61K31/553; A61P1/00; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P15/00; A61P17/02; C07C69/76; C07C211/40; C07C225/20; C07C229/46; C07C237/30; C07C255/58; C07C311/13; C07C311/21; C07C311/24; C07C317/22; C07D263/10; C07D263/58; C07D267/02
Domestic Patent References:
| JP48043734B1 | ||||
| JP52111560A | ||||
| JP59031753A |
Foreign References:
| WO1998020005A1 |
Attorney, Agent or Firm:
Shintaro Nogawa