PURPOSE: To provide an agent useful as an antiinflammatory, analgesic and antipyretic agent having cyclooxygenase-inhibiting action higher than that of indomethacin.
CONSTITUTION: The objective agent contains a thiazole compound of formula (R1 is lower alkyl; R2 and R3 are H or lower alkyl; R4 is OH, lower alkoxy or NR5R6; R5 and R6 are H or lower alkyl) or its pharmacologically permissible salt, preferably 2-[4-(4-methylthiazol-2-yl)phenyl]propionic acid, etc., as an active component. The cyclooxygenase-inhibiting action of the active component is about 5 to 6 times as large as that of indomethacin and, accordingly, the compound is useful as a cyclooxygenase-inhibiting agent effective against various diseases relevant to prostaglandins and thromboxanes. The active component is administered at a rate of usually 1-1,000mg per day in one to several divided doses.
MAEDA KAZUMI
HANADA SHUICHI
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