Title:
CYCLOPENTANE DERIVATIVE AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP3446225
Kind Code:
B2
Abstract:
PURPOSE: To provide a new compound derivative produced by reacting a specific cyclopentenone derivative with a nucleophilic reagent and deprotecting the protecting group and useful as pharmaceuticals, agricultural chemicals or their intermediates, especially as a synthetic intermediate for prostaglandins.
CONSTITUTION: The objective cyclopentane derivative expressed by formula III or formula IV and useful as a synthetic intermediate for prostaglandins, etc., can be produced by reacting a cyclopentenone derivative of formula I [R1 is 1-15C (substituted) alkyl or (substituted) phenyl; R2 and R3 are hydroxyl- protecting group] {e.g. (3R,4R)-2-methylene-3-[(S,E)-3-cyclohexyl-3-(t- butyldimethylsiloxy)-1-propene-1-yl]-4-(t-butyldimethylsiloxy)cyclopentan-1-one} with a nucleophilic reagent expressed by formula II (R4 is H or OH-protecting group; M is Li, Na, K, Mg, Ca, Ti, Zr, Ni, Cu Zn, Al, Sn, etc.) and, as necessary, deprotecting the protecting group of R4.
Inventors:
Katsuaki Miyaji
Fumie Sato
Fumie Sato
Application Number:
JP23999892A
Publication Date:
September 16, 2003
Filing Date:
August 17, 1992
Export Citation:
Assignee:
Nissan Chemical Industry Co., Ltd.
Fumie Sato
Fumie Sato
International Classes:
C07C405/00; (IPC1-7): C07C405/00
Domestic Patent References:
| JP4867257A | ||||
| JP2502009A |
Other References:
Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，１９７５年，９７（１６），４７４５−４７４６
Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，１９７５年，９７（２１），６２６０−６２６１
Ｊ．Ａｍ．Ｃｈｅｍ．Ｓｏｃ．，１９７５年，９７（２１），６２６０−６２６１
Attorney, Agent or Firm:
Takashi Kojima
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