Title:
CYCLOPROPANE DERIVATIVE AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JP3769737
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound useful as an antiviral agent.
CONSTITUTION: This is a compound of formula I (B is a purine derivative residue such as guanine-9-yl, 2-amino-6-chloropurine-9-yl and 2-acetamino-6- chloropurine-9-yl), e.g. 2-amino-6-chloro-9-(3'-oxa-2'-oxobicyclo[3,1,0]hexane-1'-yl) methylpurine. A compound of formula I is obtained by substituting the hydroxyl group of (3-oxa-2-oxobicyclo[3,1,0]hexane-1-yl)methanol of formula II with a leaving group followed by the reaction with a purine derivative. Further, the reduction of a compound of formula I can lead to a compound of formula III.
Inventors:
Tomoyuki Onishi
Naoshi Tsuji
Toshihiro Matsuzawa
Naoshi Tsuji
Toshihiro Matsuzawa
Application Number:
JP17549594A
Publication Date:
April 26, 2006
Filing Date:
July 27, 1994
Export Citation:
Assignee:
AJINOMOTO CO.,LTD.
International Classes:
C07D473/04; C07C62/02; C07C235/40; C07D307/93; C07D473/00; C07D473/16; C07D473/18; C07D473/32; C07D473/34; C07D473/40; (IPC1-7): C07D473/00; C07D307/93; C07D473/18; C07D473/32; C07D473/34
Domestic Patent References:
| JP578357A |
Other References:
Chemical Abstracts,1967年,Vol.66,p.9778,abstract no.104651s
Helvetica Chimica Acta,1989年,Vol.72,p.1301-1310
Helvetica Chimica Acta,1989年,Vol.72,p.1301-1310
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama