タンパク質の部位特異的結合用のシステイン含有ペプチドタグ

Japanese Patent JP2008535485

A

The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety bound to the targeting moiety; the biological conjugate having a covalent bond between the thiol group of SEQ ID NO:2 and a functional group in the binding moiety. The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID NO:2 and the polypeptide sequence of a selected targeting protein; and (b) a binding moiety that comprises an adapter protein, the adapter protein having a thiol group; the biological conjugate having a disulfide bond between the thiol group of SEQ ID NO:2 and the thiol group of the adapter protein. The present invention is also directed to biological sequences employed in the above biological conjugates, as well as pharmaceutical preparations and methods using the above biological conjugates.

Becker, marina, buoy.
Becker, Joseph, M.

JP2008501926A

September 04, 2008

March 10, 2006

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Shibutech, Inc.

C12N15/09; A61K9/127; A61K38/22; A61K45/00; A61K47/02; A61K47/04; A61K47/10; A61K47/12; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61K47/44; A61K47/46; A61K47/48; A61K49/00; A61P9/00; C07K7/08; C07K14/32; C07K14/47; C07K14/475; C07K14/485; C07K14/52; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/22; C12N15/87; C12Q1/02

JP2004516809A

2004-06-10

WO2005115477A2

2005-12-08

Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio

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