Title:
寄生虫疾患を治療するためのシステインプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP5511676
Kind Code:
B2
Abstract:
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, stronglyoidiasis, trichostrongyliasis, trichomoniasis or cestodiasis.
Inventors:
Isabel, Elise
Melon, christophe
Beaulieu, Kristian
Melon, christophe
Beaulieu, Kristian
Application Number:
JP2010535184A
Publication Date:
June 04, 2014
Filing Date:
November 26, 2008
Export Citation:
Assignee:
MERCK CANADA INC.
International Classes:
C07C255/60; A61K31/277; A61K31/40; A61K31/4245; A61K31/4406; A61K31/4425; A61K31/495; A61K31/5375; A61K45/00; A61P33/00; A61P33/02; A61P33/04; A61P33/06; A61P33/10; A61P33/12; A61P43/00; C07C255/44; C07C311/37; C07C317/32; C07C317/50; C07C321/24; C07D207/335; C07D213/57; C07D213/89; C07D271/06; C07D295/12; C07D295/16
Domestic Patent References:
| JP2005526753A | ||||
| JP5004958A |
Foreign References:
| WO2007012180A1 |
Other References:
Leger, Serge 他,Primary amides as selective inhibitors of cathepsin K,Bioorganic and Medicinal Chemistry Letters,2007年,17(15),4328-4332
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama