Title:
細胞骨格活性RHOキナーゼインヒビター化合物、組成物及び使用
Document Type and Number:
Japanese Patent JP5511385
Kind Code:
B2
Abstract:
The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions.
Inventors:
Lamp, John W.
Watson, Paul S.
Slade, David Jay.
Peterson, Ward M.
Clean, Christopher S.
Bittitow, Jason El.
Dicamp, Jonathan Bryan
Pells, Nicholas F.
Watson, Paul S.
Slade, David Jay.
Peterson, Ward M.
Clean, Christopher S.
Bittitow, Jason El.
Dicamp, Jonathan Bryan
Pells, Nicholas F.
Application Number:
JP2009541644A
Publication Date:
June 04, 2014
Filing Date:
December 18, 2007
Export Citation:
Assignee:
Inspire Pharmaceuticals, Incorporated
International Classes:
C07D401/12; A61K31/4725; A61K31/5377; A61P27/02; A61P27/06; A61P43/00; A61K31/4439; A61K31/454; A61K31/4545; A61K31/496; A61K31/55; C07D401/14; C07D403/12; C07D405/14; C07D409/14; C07D413/12; C07D471/04
Domestic Patent References:
JP2004527499A | ||||
JP2009501130A |
Foreign References:
WO2001056988A1 | ||||
WO2002100833A1 | ||||
WO2004024717A1 | ||||
WO2006127587A1 | ||||
WO2006051311A1 |
Other References:
TAKAMI,A. et al.,Design and synthesis of Rho kinase inhibitors (I),Bioorg.Med.Chem.,2004年,Vol.12, No.9,p.2115-2137
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama