Title:
Cytotoxic benzodiazepine derivative
Document Type and Number:
Japanese Patent JP6216356
Kind Code:
B2
Abstract:
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
Inventors:
Lee, Way
Miller, Michael
Fishkin, Nathan
Chari, Ravi V. Jay
Miller, Michael
Fishkin, Nathan
Chari, Ravi V. Jay
Application Number:
JP2015202619A
Publication Date:
October 18, 2017
Filing Date:
October 14, 2015
Export Citation:
Assignee:
Immunogen Incorporated
International Classes:
C07D519/00
Foreign References:
| WO2010091150A1 |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Hirose Shinobu
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Hirose Shinobu