Title:
【発明の名称】D-ペントフラノース誘導体及びその製造法
Document Type and Number:
Japanese Patent JP3046359
Kind Code:
B2
Abstract:
The present invention relates to D-pentofuranose derivatives represented by the following formulas (1) through (4): (wherein A represents a chlorobenzoyl group; R<1> represents a hydrogen atom, an aliphatic lower acyl group, a substituted or unsubstituted benzoyl group; each of X and Y represents a lower alkyl group; Z represents an ethynyl group or tri-lower alkyl silylethynyl group; the sugar moiety in formula (1) represents xylose; and the sugar moiety of each of formulas (3) and (4) represents ribose). The present invention also relates to a process for preparing the compound (2) characterized by oxidizing the compound of formula (1) with a hypochlorite in the presence of a catalytic amount of 2,2,6,6-tetramethylpiperidinoxy compound. These compounds are useful as intermediates in the synthesis of 3'-C-substituted ribonucleoside derivatives having excellent antitumor activities.
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Inventors:
Makoto Nomura
Hideki Kazuno
Tsutomu Sato
Washizu Masato
Motoaki Tanaka
Akira Matsuda
Tetsuji Asao
Hideki Kazuno
Tsutomu Sato
Washizu Masato
Motoaki Tanaka
Akira Matsuda
Tetsuji Asao
Application Number:
JP54071597A
Publication Date:
May 29, 2000
Filing Date:
April 24, 1997
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
C07H9/04; C07H13/04; C07H19/04; (IPC1-7): C07H13/08
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)