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Title:
D-PENTOFURANOSE DERIVATIVE AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP2000154197
Kind Code:
A
Abstract:

To obtain a new D-pentofuranose derivative useful as an intermediate for industrially synthesizing a 3'-C-substituted ribonucleotide derivative which has an excellent antitumor activity, by reacting a 4-chlorobenzoyl halide with a D-pentofuranose compound.

This new D-pentofuranose derivative of formula I [R1 is H, an aliphatic lower acryl, (substituted) benzoyl or a lower alkyloxycarbonyl; Z is ethynyl which may be substituted by a trialkylsilyl group; the sugar portion is ribose]. The compound of formula I is useful as an intermediate for industrially synthesizing a 3'-C-substituted ribonucleotide derivative which has an excellent antitumor activity and is useful as an antitumor agent, etc. The D- pentofuranose derivative of formula I is obtained by reacting a compound of formula II (X and Y are each a lower alkyl) with a 4-chlorobenzoyl halide, oxidizing the reaction product, reacting the obtained 3-ketofuranose of formula III with a Grignard reagent, and subsequently removing the protecting group.


Inventors:
Nomura, Makoto
Kazuno, Hideki
Sato, Tsutomu
Washisu, Masato
Tanaka, Motoaki
Matsuda, Akira
Asao, Tetsuji
Application Number:
JP2000000014691
Publication Date:
June 06, 2000
Filing Date:
April 24, 1997
Export Citation:
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Assignee:
TAIHO YAKUHIN KOGYO KK
International Classes:
C07H13/08; C07H13/12; (IPC1-7): C07H13/08; C07H13/12
Attorney, Agent or Firm:
有賀 三幸 (外3名)