Title:
グルタメートゲートを具えた塩化物チャンネルをコードするDNA
Document Type and Number:
Japanese Patent JP3862278
Kind Code:
B2
Abstract:
DNA encoding glutamate and avermectin-sensitive chloride channels have been cloned and characterized. The protein is capable of forming channels selectively opened with either avermectin or glutamate. The cDNA has been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified. Receptor modulators active in the method disclosed herein are useful as ectoparasiticides, antiparasitic, anthelmenthic, acaracidal and insecticide agents.
Inventors:
Curry, Doris F
Arena, Jiuji Phu
Pairless, Philip S
Li Yu, Ken Kay
Arena, Jiuji Phu
Pairless, Philip S
Li Yu, Ken Kay
Application Number:
JP53343596A
Publication Date:
December 27, 2006
Filing Date:
May 01, 1996
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
C12N15/09; G01N33/53; A61K31/70; A61K45/00; A61P33/00; C07K14/435; C07K14/705; C07K16/18; C12N1/21; C12P21/02; G01N33/577; A61K38/00; C12R1/19
Other References:
Nature, 1994年,vol.371, no.6499, p.707-711
Insect Biochem. Mol. Biol., 1995年 1月,vol.25, no.1, p.11-17
Insect Biochem. Mol. Biol., 1995年 1月,vol.25, no.1, p.11-17
Attorney, Agent or Firm:
Yoshio Kawaguchi
Takeshi Funayama
Naoya Fushimi
Takeshi Funayama
Naoya Fushimi