Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ジスルフィドリンカーを有する分解性ポリエチレングリコール誘導体
Document Type and Number:
Japanese Patent JP7101939
Kind Code:
B2
Abstract:
To provide a degradable polyethylene glycol derivative in which polyethylene glycol chains are linked by a disulfide linker capable of accurately controlling the degradation rate under different reductive environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body is able to be accurately controlled. A degradable polyethylene glycol derivative represented by formula (1). R1, R2, R3and R4represent each independently a hydrogen atom or a hydrocarbon group having from 1 to 6 carbon atoms, and at least one of R1, R2, R3and R4is the hydrocarbon group; P1is a straight-chain or branched polyethylene glycol chain having a number of ethylene glycol units of 3 or more; P2is a straight-chain polyethylene glycol chain having a number of ethylene glycol units of 3 or more; w is an integer of 1 to 8; u is an integer of 1 to 10; X1is a chemically reactive functional group; and Z1, Z2and Z3are each independently a selected divalent spacer.

Inventors:
Kota Tange
Hiroki Yoshioka
Takuma Grainzaki
Masaki Kamiya
Application Number:
JP2018055587A
Publication Date:
July 19, 2022
Filing Date:
March 23, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
NOF CORPORATION
International Classes:
C08G65/334
Domestic Patent References:
JP2009527581A
JP2007533750A
Attorney, Agent or Firm:
Masuda Hosoda
Sumio Aoki