２－置換フラン誘導体へのアルファ－、ベータ－ジヒドロキシカルボニル化合物の脱水及び環化

Japanese Patent JP7446239

B2

Processes are disclosed for the synthesis of 2-substituted furan derivatives, such as furan dicarboxylic acid (FDCA), from a starting compound or substrate having a carbonyl functional group (C═O), with hydroxy-substituted carbon atoms at alpha (α) and beta (β) positions, relative to the carbonyl functional group. According a particular embodiment, an α-, β-dihydroxy carboxylate is dehydrated to form a dicarbonyl intermediate by transformation of the α-hydroxy group to a second carbonyl group and removal of the β-hydroxy group. The dicarbonyl intermediate undergoes cyclization and dehydration, to produce the 2-substituted furan derivative. Optionally, a further step of oxidation may be carried out, for example to convert a hydroxymethyl group, as a 5-substituted about the furan ring, to a carboxy group of FDCA.

JP2009524678	Phenyl and pyridyl compounds for inflammation and immune related applications
JPH11513397	INDUSTRIAL APPLICABILITY: Oxyaminooxime ether, its production, an intermediate for its production, and a method for using it for controlling harmful fungi and harmful animals.
WO/2008/141976	DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS

Brazil, James
Logness, Donald

JP2020555384A

March 08, 2024

April 04, 2019

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Archer-Daniels-Midland Company

C07D307/68

WO2015189481A1
KR1020170003028A
WO2013049711A1

The Journal of Physical Chemistry C,2015年,119,17117-17125
ChemSusChem,2011年,4(8),1049-1051
ChemSusChem,2015年,8(7),1151-1155

Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito

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