Title:
DELTA 9(11)- AND DELTA 16-21-CHLORO-20- KETOSTEROID OF PREGNANE AND D-HOMO-PREGNANE SERIES AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS57159799
Kind Code:
A
Abstract:
DELTA <1><6> and DELTA <1><7>-21-chloro-20-keto steroids of the formula wherein n is 1 or 2, C1@C2 and C9@C11 represents a CC-single or CC-double bond, R1 is H or OH, R2 is H or CH3, R3 is H or F wherein, when R3 = F, C9@C11 is a CC-single bond, and R4 is H, CH3, or F, are valuable intermediates for preparation of highly effective, known steroids. A process for preparing these compounds involves heating the corresponding 11 beta - and/or 17 alpha - or l7a alpha -nitrooxy-21-mesyloxy-20-keto steroids with lithium chloride in a dipolar aprotic solvent at temperatures above room temperature.
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Inventors:
KURAUSU ANEN
HENRII RAURENTO
HERUMUUTO HOOFUMAISUTAA
HENRII RAURENTO
HERUMUUTO HOOFUMAISUTAA
Application Number:
JP3599882A
Publication Date:
October 01, 1982
Filing Date:
March 09, 1982
Export Citation:
Assignee:
SCHERING AG
International Classes:
C07J7/00; C07J13/00; C07J31/00; C07J41/00; C07J63/00; C07J71/00; A61K31/58; (IPC1-7): C07J7/00; C07J63/00
Foreign References:
| US4113722A | 1978-09-12 |