Title:
Dendritic cell response gene revelation, a constituent, and directions for use for the same
Document Type and Number:
Japanese Patent JP2016515383
Kind Code:
A
Abstract:
本発明は、概して、１つまたは複数の樹状細胞（ＤＣ）応答、例えば、樹状細胞成熟、１つまたは複数の樹状細胞抗ウイルス応答および／または１つまたは複数の樹状細胞炎症応答をモジュレートし、制御しまたは他の形でそれに影響を与える調節ネットワークを同定するための組成物および方法、さらに、１つまたは複数の樹状細胞応答をモジュレートし、制御しまたは他の形でそれに影響を与える調節ネットワークを種々の治療および／または診断指標において利用するための組成物および方法に関する。
Inventors:
Aviv Rejev
Alexander K. Schalek
Rahul Satilla
Hong Khun Park
Alexander K. Schalek
Rahul Satilla
Hong Khun Park
Application Number:
JP2016503400A
Publication Date:
May 30, 2016
Filing Date:
March 17, 2014
Export Citation:
Assignee:
The Broad Institute Incorporated
PRESIDENT AND FELLOWS OFHARVARD COLLEGE
Massachusetts Institute of Technology
PRESIDENT AND FELLOWS OFHARVARD COLLEGE
Massachusetts Institute of Technology
International Classes:
C12N5/0784; C12N15/09; C12Q1/68
Domestic Patent References:
| JP2005500842A | 2005-01-13 | |||
| JP2006505280A | 2006-02-16 | |||
| JP2012521199A | 2012-09-13 | |||
| JP2014513725A | 2014-06-05 |
Other References:
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DAVORKA MESSMER, ET AL.: "The global transcriptional maturation program and stimuli-specific gene expression profiles of human", INTERNATIONAL IMMUNOLOGY, vol. 15, JPN6018007037, 2003, pages 491 - 503, ISSN: 0003747976
YUKO KAWAKAMI, ET AL.: "Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3", PNAS, vol. 103, JPN6018007039, 2006, pages 153 - 158, XP055049232, ISSN: 0003747977, DOI: 10.1073/pnas.0509784103
NATHALIE LAMBRECHTS, ET AL: "Functionality and specificity of gene markers for skin sensitization in dendritic cells", TOXICOLOGY LETTERS, vol. 203, JPN6018007041, 2011, pages 106 - 110, XP028201876, ISSN: 0003747978, DOI: 10.1016/j.toxlet.2011.02.015
ELIZABETH P. ST. JOHN, ET AL: "Dendritic cell activation and maturation induced by mucosal fluid from women with bacterial vaginosi", CLINICAL IMMUNOLOGY, vol. 125, JPN6018007042, 2007, pages 95 - 102, XP022240715, ISSN: 0003747979, DOI: 10.1016/j.clim.2007.06.004
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe