Title:
Dengue virus recombination subunit Scan vaccine
Document Type and Number:
Japanese Patent JP6018575
Kind Code:
B2
Abstract:
The present invention provides dengue virus vaccines and immunogenic compositions for administration to human subjects. The vaccine compositions of the present invention comprise recombinantly produced monomeric and/or dimeric forms of truncated dengue virus envelope glycoprotein that, when formulated together with an adjuvant and a pharmaceutically acceptable carrier, induce balanced tetravalent immune responses. In preferred embodiments of the compositions described herein, the DEN4 protein component is a dimeric form of DEN4. The compositions are designed to be acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. Also provided herein are methods of inducing a protective immune response in a human patient population by administering the compositions described herein to the patients.
Inventors:
Coller, Beth-Anne Griswold
Pie, Bidya Bee
Parks, Day Elliot
Yermen, Michel
BETTO, Andrew Jei
Mateiaku, Timothy
Pie, Bidya Bee
Parks, Day Elliot
Yermen, Michel
BETTO, Andrew Jei
Mateiaku, Timothy
Application Number:
JP2013536813A
Publication Date:
November 02, 2016
Filing Date:
October 27, 2011
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
A61K39/12; A61K39/39; A61P31/12; A61P37/04; C07K14/18
Domestic Patent References:
| JP2001511459A |
Foreign References:
| WO2004052293A1 |
Other References:
Vaccine,2010 Mar 24,28(15),p.2705-15,Epub 2010 Jan 2
J Virol.,2005 May,79(9),p.5516-28
Am J Trop Med Hyg.,2002 Mar,66(3),p.264-72
ウイルス,2002,52(1),p.15-20
J Virol.,2005 May,79(9),p.5516-28
Am J Trop Med Hyg.,2002 Mar,66(3),p.264-72
ウイルス,2002,52(1),p.15-20
Attorney, Agent or Firm:
Yousuke Kawasaki
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama