Title:
デオキシノジリマイシン誘導体及び該誘導体のグルコシルセラミダーゼ阻害剤としての用途
Document Type and Number:
Japanese Patent JP4564108
Kind Code:
B2
Abstract:
Deoxynojirimycin derivatives containing a large hydrophobic moiety, such as cholesterol or adamantame-methanol, linked through a spacer, such as pentamethylene, to the nitrogen atom of deoxynojirimycin, and salts thereof, inhibit glucosylceramidase and may be useful in the treatment of diseases involving a ceramide-mediated signaling process, such as Gaucher disease.
Inventors:
Aerz, Johannes Maria Francis Cus Heraldus
Pandit, Upendra Kumar
Kormen, Herrit Yang
Overkraft, Hermann Steven
Vianero, Paola
Pandit, Upendra Kumar
Kormen, Herrit Yang
Overkraft, Hermann Steven
Vianero, Paola
Application Number:
JP50587698A
Publication Date:
October 20, 2010
Filing Date:
July 14, 1997
Export Citation:
Assignee:
Genzyme Corporation
International Classes:
C07D211/46; A61K31/445; A61K31/575; A61P43/00; C07J9/00; C07J43/00
Domestic Patent References:
| JP4342567A | ||||
| JP2131425A | ||||
| JP2306962A | ||||
| JP61200967A | ||||
| JP56133267A | ||||
| JP56007763A |
Foreign References:
| WO1995022975A1 | ||||
| DE3024901A |
Other References:
The Journal of Biological Chemistry, 1994年, Vol.269, No.11, pp.8362-8365
The Journal of Biological Chemistry, 1991年, Vol.266, No.22, pp.14504-14510
Glycobiology, 1994年, Vol.4, No.2, pp.141-149
The Journal of Biological Chemistry, 1991年, Vol.266, No.22, pp.14504-14510
Glycobiology, 1994年, Vol.4, No.2, pp.141-149
Attorney, Agent or Firm:
Junzo Watanabe