NEW MATERIAL: 1,2:3,5-Di-O-isopropylidene-6-deoxy-6-thio-3' (N',N'- dimethylamino-n-propyl)-α,D-glucofuranose, 1,2-O-isopropylidene-3-O-n-heptyl-α,D- glucofuranose, 1,2-O-isopropylidene-3-deoxy-3-amino-3'-(propane-1'-ol)-α,D- arofuranose and 1,2:3,5-di-O-isopropylidene-6-O-2'-(N'-ethylpyrrolidyl)-α,D- glucofuranose.
USE: Therapeutic agents for inflammatory and autoimmune disorders such as psoriasis, atopic dermatitus, rheumatoid arthritis, osteoarthritis, scleroderma and systemic lupus erythematosus.
PROCESS: 1,2-O-isopropylidene-α,D-glucofuranose is added to a solvent and a non-reactive org. base and in addition, the mixture is brought into contact with trimethylacetyl chloride and the formed product is dissolved in 2,2- dimethyloxypropane and NaOH aq. soln. is added therein.
SUDAASHIYAN KEE ARORA
ARUBAATO BAAJIESU TOOMASU
