Title:
誘導体化３−スチリル−セファロスポリン
Document Type and Number:
Japanese Patent JP6403289
Kind Code:
B2
Abstract:
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.
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Inventors:
Sutton, Larry Dee.
Yu, Sofia
Yu, Sofia
Application Number:
JP2016501556A
Publication Date:
October 10, 2018
Filing Date:
March 12, 2014
Export Citation:
Assignee:
GLADIUS PHARMACEUTICALS CORPORATION
International Classes:
C07D501/20; A61K31/546; A61P31/00; A61P43/00
Domestic Patent References:
| JP2011500586A | ||||
| JP2069484A | ||||
| JP4273882A | ||||
| JP63211286A |
Foreign References:
| US20100261700 | ||||
| US4258040 | ||||
| WO2002024707A1 |
Other References:
PubChem Compound,2012年 9月24日,PubChem CID: 60173106,検索日:2017年12月15日
PubChem Compound,2013年 9月23日,PubChem CID: 71714552,検索日:2017年12月15日
T. G. C. BIRD et al.,Pharmacokinetics of Catechol Cephalosporins. The Effect of Incorporating Substituents into the Catechol Moiety on Pharmacokinetics in a Marmoset Model,Journal of Medicinal Chemistry,1992年,35(14),pp. 2643-2651
Myung Hee Jung et al.,Synthesis and Antibacterial Activity of C3-(Substituted)vinyl Cephalosporins. VI,Korean Journal of Medicinal Chemistry,1998年,8(2),pp. 92-95
Hun Yeong Koh et al.,Synthesis and Structure-Activity Relationships of Cephalosporins having a Catechol Moiety,Korean Journal of Medicinal Chemistry,1996年,6(2),pp. 333-338
PubChem Compound,2013年 9月23日,PubChem CID: 71714552,検索日:2017年12月15日
T. G. C. BIRD et al.,Pharmacokinetics of Catechol Cephalosporins. The Effect of Incorporating Substituents into the Catechol Moiety on Pharmacokinetics in a Marmoset Model,Journal of Medicinal Chemistry,1992年,35(14),pp. 2643-2651
Myung Hee Jung et al.,Synthesis and Antibacterial Activity of C3-(Substituted)vinyl Cephalosporins. VI,Korean Journal of Medicinal Chemistry,1998年,8(2),pp. 92-95
Hun Yeong Koh et al.,Synthesis and Structure-Activity Relationships of Cephalosporins having a Catechol Moiety,Korean Journal of Medicinal Chemistry,1996年,6(2),pp. 333-338
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi