DERIVATIVE OF PHYTOSTEROL AND/OR PHYTOSTANOL

Title:

DERIVATIVE OF PHYTOSTEROL AND/OR PHYTOSTANOL

Document Type and Number:

Japanese Patent JP2000159792

Kind Code:

A

Abstract:

To obtain the subject compound capable of remarkably reducing both serum cholesterol and triglyceride by producing the compound from a phytosterol and/or a phytostanol and a specific polyunsaturated fatty acid.

This phytosterol and/or phytostanol derivative comprises (A) a phytosterol and/or a phytostanol and (B) a 18-22C polyunsaturated fatty acid containing at least 3 unsaturated carbon-carbon double bonds. β-Sitosterol is preferable as the component A. Eicosapentaenoic acid or docosahexaenoic acid is preferable as the component B. The objective compound is obtained, for example, by transesterifying the liberated component A with the polyunsaturated fatty acid ester. The reaction is preferably carried out by using a sodium alkoxide of a 1-4C alcohol as a catalyst in the absence of a reaction solvent at 80-140°C under 133-6650 Pa.

Inventors:

BURDICK DAVID CARL (CH)
MOINE GERARD (FR)
RAEDERSTORFF DANIEL (FR)
WEBER PETER (DE)

Application Number:

JP33077099A

Publication Date:

June 13, 2000

Filing Date:

November 22, 1999

Export Citation:

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Assignee:

HOFFMANN LA ROCHE (CH)

International Classes:

A23D9/013; A23L1/30; A23L33/20; A61K31/56; A61K31/575; A61P3/04; A61P3/06; C07J9/00; C11B1/00; (IPC1-7): C07J9/00; A23L1/307; A61K31/575; A61P3/04; A61P3/06

Attorney, Agent or Firm:

Hajime Tsukuni (1 person outside)

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