Title:
3-(2-オキソ-〔1,3′〕ビピロリジニル-3-イリデンメチル)-セフェムの誘導体
Document Type and Number:
Japanese Patent JP3872955
Kind Code:
B2
Abstract:
The present invention is concerned with new compounds of formula (I) wherein R<1> is hydrogen, C1-6-alkyl, optionally substituted by fluoro, or C3-6-cycloalkyl; R<2> is hydrogen or a group selected from -CH2C(=CHR)-COOR, -CH2OCOR, -CH(R)OCOR, -CH(R)OCOOR, -CH(OCOR)OCOR, -CH2COCH2OCOR and (II); R<3> is hydrogen or group selected from -CH2C(=CH2)-COOR, -COOCH2C(=CHR)-COOR, -COOCH2OCOR, -COOCH(R)OCOR, -CO CH(R)OCOOR, -COOCH(OCOR)OCOR, -COOCH2COCH2OCOR, and (III); with the proviso that one of R<2> and R<3> is hydrogen and the other of R<2> and R<3> is different from hydrogen, R is hydrogen or C1-6-alkyl; R<4> is hydrogen or hydroxy, R<5> is hydrogen or omega -hydroxyalkyl; and X is CH or N, as well as pharmaceutically acceptable salts of said compounds and hydrates of said compounds and of their salts, and with the use of compounds of formula (I) and of pharmaceutically acceptable salts of said compounds and hydrates of said compounds and of their salts for the manufacture of pharmaceutical preparations containing such compounds.
Inventors:
Hewesen, Paul
Yubschwerlen, Christian
Speclan, Jean-Luc
Yubschwerlen, Christian
Speclan, Jean-Luc
Application Number:
JP2000554745A
Publication Date:
January 24, 2007
Filing Date:
June 07, 1999
Export Citation:
Assignee:
Basilea Pharmaceutica AG
International Classes:
C07D501/56; A61K31/545; A61K31/546; A61P31/04; C07D501/00
Foreign References:
| EP0849267A1 |
Other References:
J.Antibiot.,Vol.45,No.8,p.1358-1364(1992)
J.Med.Chem.,Vol.39,No.2,p.480-486(1996)
J.Med.Chem.,Vol.39,No.2,p.480-486(1996)
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda