エトポシドおよび類似体の誘導体、ならびにそれを含有する医薬組成物 - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Title:

エトポシドおよび類似体の誘導体、ならびにそれを含有する医薬組成物

Document Type and Number:

Japanese Patent JP2005511550

Kind Code:

A

Abstract:

The invention relates to compounds having the following formula (I), in which: Ra represents a sugar moiety, an arylamino group, or an alkyl group comprising at least one amino group, Rb represents an halogen atom, an halogenoalkyl group, a nitro group, or a group -NR(COR') in which R and R', independently from each other, represent an alkyl group, R1 represents H, or a protecting group for COOH group, R2, R3, and R4, independently from each other, represent H, or a protecting group for OH group. The invention also relates to the use of such compounds in pharmaceutical compositions for the treatment of cancers.

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Inventors:

Monelle, Claude
Schmidt, Frederick

Application Number:

JP2003538174A

Publication Date:

April 28, 2005

Filing Date:

October 25, 2002

Export Citation:

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Assignee:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
INSTITUT CURIE

International Classes:

A61K31/7036; A61K31/7048; A61P35/00; A61P35/02; A61P43/00; C07H7/033; C07H15/203; C07H17/04; (IPC1-7): C07H17/04; A61K31/7036; A61K31/7048; A61P35/00; A61P35/02; A61P43/00; C07H15/203

Attorney, Agent or Firm:

Hajime Tsukuni
Fumio Shinoda

Previous Patent: JP2005511549

Next Patent: ２−アラルコキシアデノシン及び２−アルコキシアデノシンの合成