To obtain the subject novel compound highly safe and excellent in suppressing action on lipid peroxidization, suppressing action on macrophage foaming, suppressing action on growth of LDL oxide, etc., useful as prevention or therapeutic agent for disease ischemia, arteriosclerosis, irritation, etc.
The compounds are expressed in formula I (R0 is H, an alkyl, an alkyloxy; either one of R1, R3 is H and the rest forms naphthalene ring or oxygen containing bicyclic heterocyclic ring with R2 and benzene ring; W is O, S, etc.; R4 is an amino, an alkyl, OR5 is a (protected) hydroxyl) or their pharmacologically permissible salts, for example, 2-[3-(3-pyridylmethyl)ureide]-4,5- methylenedioxyphennol. The compound having S atom or O atom as W and R4 is an amino group in formula I is obtained by carrying out the reaction of an aniline derivatives of formula II (OR51 is same to OR5) or their salts and phosgene, triphosgene or thiophosgene, and reacting the amine derivatives of the compound of formula III (R4 is amino) or their salts.
OMIZU HIROSHI
HASHIMURA YOSHIMASA
KUBOTA HITOSHI
SAITO KEIKO
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