PURPOSE: A dermal drug for external use, obtained by incorporating dextran sulfate or a salt thereof and glycyrrhetinic acid or a derivative thereof with other components and capable of preventing and improving the skin roughening and further preventing loosening of the skin, disappearance of gloss, etc., and preventing the aging.

CONSTITUTION: A dermal drug for external use obtained by incorporating one or two or more of (A) dextran sulfate expressed by formula I (R is SO3Na or H), preferably having 0.02W0.05, particularly 0.02W0.03 intrinsic viscosity using 1M saline solution at 25°C and 2W20wt%, particularly 16W19wt% sulfur content or a salt thereof, e.g. alkali salt or organic amine salt such as triethanolamine, with (B) glycyrrhetinic acid expressed by formula II and a derivative thereof, e.g. methyl glycyrrhetinate, in with other components. The amounts of the components (A) and (B) to be incorporated baszed on the total weight of the dermal drug for the external use are respectively as follows; 0.005W2wt%, particularly 0.05W0.5wt%.