Title:
【発明の名称】2-置換ベンゾイル-シクロアルキル-1-カルボン酸誘導体
Document Type and Number:
Japanese Patent JP2001514634
Kind Code:
A
Abstract:
2-(substituted benzoyl)-cycloalkyl-1-carboxylic acids of formula (I) wherein E is a C1-C4 alkylene chain in which a carbon atom is optionally substituted; each of R and R1, being the same or different, is hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, SOR4 or SO2R4; R2 is hydrogen or -N(R7R8) in which each of R7 and R8 is, independently, hydrogen, C1-C6 alkyl, benzyl, phenyl, hydroxy, C1-C6 alkoxy, benzyloxy or one of R7 and R8 is hydrogen and the other is COR9; R3 is hydroxy, C1-C6 alkoxy, phenoxy, benzyloxy or a group -N(R12R13); and pharmaceutically acceptable salts thereof, have kynurenine-3-hydroxylase enzyme inhibitor activity.
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Inventors:
Barashi, Mario
Giordani, Antonio
Pevaretro, Paolo
Roberto Peritzkiari
Speciale, Carmela
Giordani, Antonio
Pevaretro, Paolo
Roberto Peritzkiari
Speciale, Carmela
Application Number:
JP53912398A
Publication Date:
September 11, 2001
Filing Date:
February 16, 1998
Export Citation:
Assignee:
Farmacia e Appzyon Esset Pear
International Classes:
A61K31/165; A61K31/192; A61K31/216; A61P9/10; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07C51/09; C07C62/28; C07C62/38; C07C67/14; C07C69/743; C07C69/757; C07C227/18; C07C229/48; C07C233/60; C07C233/81; C07C235/82; C07C237/24; C07C259/08; C07C271/24; C07D263/42; C07C271/64; C07C311/51; C07D263/52; (IPC1-7): C07C62/28; A61K31/165; A61K31/192; A61K31/216; A61P9/10; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07C51/09; C07C67/14; C07C69/743; C07C227/18; C07C229/48; C07C235/82; C07C237/24; C07C259/08; C07C271/24; C07C271/64; C07C311/51
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)