Title:
【発明の名称】プレプロインスリンのインスリンへの酵素的変換方法
Document Type and Number:
Japanese Patent JP3005335
Kind Code:
B2
Abstract:
A process for the specific hydrolysis of the amino-acid chain of preproinsulins to give the corresponding intermediates with the aid of clostripain is described, and these intermediates can be converted where appropriate with carboxypeptidase B into the corresponding insulins.
Inventors:
Michael delucyuk
Claus-Peter Coller
Lieu Deiger Marc Vault
Johannes Maives
Claus-Peter Coller
Lieu Deiger Marc Vault
Johannes Maives
Application Number:
JP22324391A
Publication Date:
January 31, 2000
Filing Date:
September 04, 1991
Export Citation:
Assignee:
HOECHST AKTIENGESELLSCHAFT
International Classes:
C07K14/62; C12N9/48; C12N15/09; C12P21/02; C12P21/06; C12N9/52; (IPC1-7): C12P21/06; C07K14/62; C12N15/09; C12P21/02
Attorney, Agent or Firm:
Chika Takagi (2 outside)