Title:
【発明の名称】ボロン酸含有ポリマー由来のゲルおよび多層表面構造
Document Type and Number:
Japanese Patent JP2002523476
Kind Code:
A
Abstract:
Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form crosslinked hydrogels, which are highly swollen in water. The crosslinking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically crosslinked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step. The bioinert gel or surface coating can be used for passivating the surfaces of medical implants (especially those based on transplanted tissue), or for passivating the surfaces of tissues in situ, decreasing the incidence or severity of such pathologic conditions as the formation of post-surgical adhesions, and thrombosis following angioplasty.
Inventors:
Hubbell, Jeffrey A.
Elbert, Donald El.
Winblade, Natalie Dee.
Elbert, Donald El.
Winblade, Natalie Dee.
Application Number:
JP2000567256A
Publication Date:
July 30, 2002
Filing Date:
August 27, 1999
Export Citation:
Assignee:
Eid Ghentsch Technische Houchur Zurich
Hubbell, Jeffrey A.
Hubbell, Jeffrey A.
International Classes:
A61L27/00; A61L27/34; A61L29/08; A61L31/10; C08F220/56; C08F230/06; C09D133/26; C09D143/00; C09D185/04; A61K9/48; C09D201/02; (IPC1-7): A61K9/48; A61L27/00; C08F220/56; C08F230/06; C09D185/04; C09D201/02
Domestic Patent References:
| JP2003527874A | 2003-09-24 | |||
| JPH06339367A | 1994-12-13 | |||
| JPH05310844A | 1993-11-22 | |||
| JPH09255018A | 1997-09-30 | |||
| JPH07503943A | 1995-04-27 | |||
| JPS62192170A | 1987-08-22 |
Foreign References:
| WO1999010022A2 | 1999-03-04 |
Attorney, Agent or Firm:
Shusaku Yamamoto