Title:
【発明の名称】治療応答を予測するためのゲノム多形現象
Document Type and Number:
Japanese Patent JP2003521896
Kind Code:
A
Abstract:
The present invention relates to the use of genomic polymorphism to provide individualized therapeutic regimens to treat patients suffering from diseases such as cancer. The invention discloses methods for determining the efficacy or choice of chemotherapeutic drugs and regimens for use in treating a diseased patient by associating genomic polymorphism with the effectiveness of the drugs or regimens, or by associating genomic polymorphism with the intratumoral expression of a gene whereby the gene expression affects effectiveness of the drugs or regimens. In particular, the present invention provides novel methods for screening therapeutic regimens, which comprise determining a patient's genotype at a tandemly repeated 28 base pair region in the thymidilate synthase (TS) gene's 5′ untranslated region (UTR). Patients homozygous for a triple repeat will be least successfully treated with a thymidylate synthase directed drug, while those heterozygous for a triple and a double repeat will be more successfully treated, and those homozygous for a double repeat will be even more successfully treated. Those patients homozygous for the double repeat will likely suffer the least side effects from thymidylate synthase directed drugs such as 5-FU.
Inventors:
Lens, Hines-Joseph
Sangkapan-Plakat, Silla
Option
Sangkapan-Plakat, Silla
Option
Application Number:
JP2001538563A
Publication Date:
July 22, 2003
Filing Date:
November 15, 2000
Export Citation:
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA
International Classes:
A61K31/505; A61K31/513; A61K45/00; A61K48/00; A61P35/00; A61P43/00; C12N15/09; C12Q1/68; C12Q1/6886; G01N27/447; G01N33/53; G01N33/483; (IPC1-7): C12N15/09; A61K31/505; A61K31/513; A61K45/00; A61K48/00; A61P35/00; A61P43/00; C12Q1/68; G01N33/483; G01N33/53
Foreign References:
| WO1997035034A1 | 1997-09-25 | |||
| WO1997035034A1 | 1997-09-25 |
Other References:
JPN5002020172, ＷＥＩ Ｘ, ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＩＮＶＥＳＴＩＧＡＴＩＯＮ, 19960801, Ｖ９８ Ｎ３, Ｐ６１０−６１５, US
JPN6010050961, "Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｏｎｃｏｌｏｇｙ", １９９７， Ｖｏｌ．１５， Ｎｏ．１０， ｐｐ．３２２３−３２２９
JPN6010050962, "Ａｎｔｉｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ", １９９９ Ｊｕｌ−Ａｕｇ．， Ｖｏｌ．１９， Ｎｏ．４Ｂ， ｐｐ．３２４９−５２
JPN5002020173, ＭＡＲＳＨ Ｓ, ＧＥＮＯＭＩＣＳ, 19990615, Ｖ５８, Ｐ３１０−３１２
JPN5002020175, ＬＥＮＺ Ｈ Ｊ, ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＯＮＣＯＬＯＧＹ, 19960101, Ｖ１４ Ｎ１, Ｐ１７６−１８２, US
JPN6010050961, "Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｏｎｃｏｌｏｇｙ", １９９７， Ｖｏｌ．１５， Ｎｏ．１０， ｐｐ．３２２３−３２２９
JPN6010050962, "Ａｎｔｉｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ", １９９９ Ｊｕｌ−Ａｕｇ．， Ｖｏｌ．１９， Ｎｏ．４Ｂ， ｐｐ．３２４９−５２
JPN5002020173, ＭＡＲＳＨ Ｓ, ＧＥＮＯＭＩＣＳ, 19990615, Ｖ５８, Ｐ３１０−３１２
JPN5002020175, ＬＥＮＺ Ｈ Ｊ, ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＯＮＣＯＬＯＧＹ, 19960101, Ｖ１４ Ｎ１, Ｐ１７６−１８２, US
Attorney, Agent or Firm:
Takashi Ishida (4 others)