Title:
【発明の名称】インビボバイオセンサ装置および使用方法
Document Type and Number:
Japanese Patent JP2002531194
Kind Code:
A
Abstract:
Disclosed are bioluminescent bioreporter integrated circuit devices that detect select analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been genetically engineered to contain a nucleic acid segment that comprises a cis-activating response element that is responsive to the selected substance operably linked to a gene encoding a bioluminescent reporter polypeptide. In preferred embodiments, the target analyte is glucose, glucagons, or insulin. Exposure of the bioreporter to the target substance causes the response element to up-regulate the nucleic acid sequence encoding the reporter polypeptide to produce a luminescent response that is detected and quantitated. In illustrative embodiments, the bioreporter device is encapsulated on an integrated circuit that is capable of detecting the emitted light, processing the resultant signal, and then remotely reporting the results. Also disclosed are controlled drug delivery systems capable of being directly or indirectly controlled by the detection device that provide drugs such as insulin to the animal in response to the amount of target analyte present in the body fluids.
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Inventors:
Sailor, Garry S.
Simpson, Michael Elle.
Applegate, Bruce M.
Lip, Stephen A.
Simpson, Michael Elle.
Applegate, Bruce M.
Lip, Stephen A.
Application Number:
JP2000585651A
Publication Date:
September 24, 2002
Filing Date:
December 02, 1999
Export Citation:
Assignee:
Utility-Battle, LRC
THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION
International Classes:
G01N33/483; A61B5/00; A61B5/145; A61B5/1473; A61K45/00; A61K49/00; A61M37/00; A61P3/10; C12Q1/00; G01N27/30; G01N27/414; (IPC1-7): A61B5/145; A61B5/00; A61K45/00; A61K49/00; A61M37/00; A61P3/10; G01N27/30; G01N27/414; G01N33/483
Attorney, Agent or Firm:
Shusaku Yamamoto