Title:
【発明の名称】真菌細胞壁の形成を抑制する組成物及び方法
Document Type and Number:
Japanese Patent JPH10512247
Kind Code:
A
Abstract:
Disclosed herein are antifungal compositions having an oligosaccharide that includes an N-acetylhexosamine residue linked beta (1}4) to a hexose and a biologically acceptable carrier. The isolation of the fungal enzyme chitin glucan beta (1}4) transferase (CG beta (1}4)T) is disclosed along with methods for using this enzyme in an assay for antifungal agents. CG beta (1}4)T catalyses the formation of a beta (1}4) linkage between the terminal reducing N-acetylglucosamine residue of chitin and the non-reducing glucose residue of beta (1}3) linked glucans. Inhibitors of the enzyme, antifungals including such inhibitors, methods for the prevention and the treatment of fungal infections in animals and plants, and screening methods for identifying antifungals are also disclosed.
Inventors:
Coller, Roman
Cabib, enrico
Silverman, Sanford Jay
Petra Cova, Eva
Cabib, enrico
Silverman, Sanford Jay
Petra Cova, Eva
Application Number:
JP52129396A
Publication Date:
November 24, 1998
Filing Date:
January 02, 1996
Export Citation:
Assignee:
American Cyanamid Company
International Classes:
A61K31/70; A61K31/7008; A61P31/04; A61P31/10; C07H5/04; C07H7/02; C07H7/04; C07K14/37; C12N9/10; C12N9/24; C12R1/645; C12R1/725; (IPC1-7): A61K31/70; C07H5/04; C07H7/02; C07H7/04; C12N9/24
Attorney, Agent or Firm:
Masatake Shiga (2 outside)