Title:
【発明の名称】アポトーシスを変調する新規ペプチドおよび組成物
Document Type and Number:
Japanese Patent JPH11506907
Kind Code:
A
Abstract:
The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the "GD domain," which is essential both to Bak's interaction with Bcl-xL, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.
Inventors:
Chittenden, Thomas Dee
Lutz, Robert Jay
Lutz, Robert Jay
Application Number:
JP53412196A
Publication Date:
June 22, 1999
Filing Date:
May 06, 1996
Export Citation:
Assignee:
Apoptosis Technology Incorporated
International Classes:
G01N33/53; A61K38/00; A61K45/00; A61P43/00; C07K14/47; C07K16/18; C12N5/10; C12N15/09; C12P21/02; C12P21/08; C12Q1/68; G01N33/577; G01N33/68; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; C07K14/47; C07K16/18; C12N5/10; C12P21/02; C12P21/08; C12Q1/68; G01N33/53; G01N33/577
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)