Title:
【発明の名称】脊椎動物Serrate遺伝子のヌクレオチドおよびタンパク質配列およびそれらに基づく方法
Document Type and Number:
Japanese Patent JPH11507203
Kind Code:
A
Abstract:
The present invention relates to nucleotide sequences of Serrate genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the Serrate protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Serrate which comprise one or more domains of the Serrate protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, cysteine rich domain, transmembrane region, membrane-associated region, or one or more EGF-like repeats of a Serrate protein, or any combination of the foregoing. Antibodies to Serrate, its derivatives and analogs, are additionally provided. Methods of production of the Serrate proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Serrate genes, from Drosophila, chick, mouse, Xenopus and human, are provided.
Inventors:
Ish-Horowitz, David
Henrik, Domingos M. P.
Lewis, Julian H.
Mayat, Anna Em.
Artavanis-Zakonas, Spiridon
Man, Robert S.
Gray, Grace Yi.
Henrik, Domingos M. P.
Lewis, Julian H.
Mayat, Anna Em.
Artavanis-Zakonas, Spiridon
Man, Robert S.
Gray, Grace Yi.
Application Number:
JP52706196A
Publication Date:
June 29, 1999
Filing Date:
March 07, 1996
Export Citation:
Assignee:
Yale University
Imperial Cancer Research Technology, Limited
Imperial Cancer Research Technology, Limited
International Classes:
C12N15/09; A61K31/70; A61K38/00; A61K39/395; A61K48/00; A61P25/00; A61P35/00; C07K14/435; C07K14/46; C07K14/465; C07K14/47; C07K14/705; C07K16/18; C07K19/00; C12N5/10; C12P21/02; C12P21/08; C12Q1/68; G01N33/15; G01N33/53; G01N33/577; (IPC1-7): C12N15/09; A61K31/70; A61K38/00; A61K39/395; A61K48/00; C07K14/435; C07K14/47; C07K16/18; C07K19/00; C12N5/10; C12P21/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/577
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)