Title:
【発明の名称】ポリアルキレンオキシド修飾された単鎖ポリペプチド
Document Type and Number:
Japanese Patent JP2002505574
Kind Code:
A
Abstract:
The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. Such preparations of modified single chain polypeptide binding molecules have reduced immugenicity and antigenicity as well as having a longer halflife in the bloodstream as compared to the parent polypeptide. These beneficial properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications. The invention also relates to multivalent antigen-binding molecules capable of PEGylation. Compositions of, genetic constructions for, methods of use, and methods for producing PEGylated antigen-binding proteins are disclosed.
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Inventors:
White wax mark
Shore, Robert G. El.
Philpra, David Earl.
Lee, Lee Shin S.
Shore, Robert G. El.
Philpra, David Earl.
Lee, Lee Shin S.
Application Number:
JP54734798A
Publication Date:
February 19, 2002
Filing Date:
April 30, 1998
Export Citation:
Assignee:
Enson, Inc.
International Classes:
G01N33/53; A61K39/38; A61K47/48; A61P35/00; C07H21/04; C07K14/00; C07K14/715; C07K16/00; C07K16/30; C07K16/44; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12P21/08; G01N33/68; C12R1/84; (IPC1-7): C12N15/09; A61K39/38; A61P35/00; C07K14/00; C07K16/44; C12N1/15; C12P21/02
Attorney, Agent or Firm:
Shusaku Yamamoto