Title:
【発明の名称】生体液における全ドキセピンを定量するための試薬および方法
Document Type and Number:
Japanese Patent JP3071824
Kind Code:
B2
Abstract:
Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification of total doxepins is accomplished in an immunoassay employing antibodies and labeled reagents prepared with doxepin derivatives of the Formula II: II wherein Y-Z can be C=CH or N-CH2, R1 is a linking group, R2 can be H or CH3, and Q can be a detectable moiety or an immunogenic carrier material. The antibody reagent comprises antibodies which are capable of binding to total doxepins and which are produced with one or more immunogens prepared from the doxepin derivative of Formula II, and the labeled reagent is also prepared from the doxepin derivative of Formula II.
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Inventors:
Adam Twitch, Masisi
Futitsuyupo, Jefrey Earl
Rusca, Robert Y
Don Young
Futitsuyupo, Jefrey Earl
Rusca, Robert Y
Don Young
Application Number:
JP50372093A
Publication Date:
July 31, 2000
Filing Date:
July 29, 1992
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
C07D313/12; G01N33/53; G01N33/532; G01N33/533; G01N33/535; G01N33/94; C07D267/18; (IPC1-7): C07D313/12; C07D267/18; G01N33/53; G01N33/532; G01N33/533; G01N33/535
Domestic Patent References:
| JP2250A | ||||
| JP578292A | ||||
| JP59132362A |
Other References:
Ｊ．Ｌａｂｅｌｌｅｄ Ｃｏｍｐｄ．Ｒａｄｉｏｐｈａｒｍ．，２８（９），１０３７−４７（１９９０）
Ｏｒｇ．Ｐｒｅｐ．Ｐｒｏｃｅｄ．Ｉｎｔ．，２４（２），１６８−７１（１９８２）
Ｏｒｇ．Ｐｒｅｐ．Ｐｒｏｃｅｄ．Ｉｎｔ．，２４（２），１６８−７１（１９８２）
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)