Title:
【発明の名称】結合特異性を有する組換ジスルフィド安定化ポリペプチドフラグメント
Document Type and Number:
Japanese Patent JP3474574
Kind Code:
B2
Abstract:
The present invention relates to disulfide-stabilized recombinant polypeptide molecules which have the binding ability and specificity for another peptide, such as the variable region of an antibody molecule. Methods of producing these molecules and nucleic acid sequences encoding these molecules are also described. In particular, the invention discloses Fv antibody fragments stabilized by a disulfide bond connecting the VH and VL regions of the Fv fragment. The alpha and beta chains of T cell receptors may be similarly stabilized by means described in the invention.
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Inventors:
Pastan, Ira H.
Lee, Bing Cook
Jun, Sun-hee
Brinkmann, Ulrich
Lee, Bing Cook
Jun, Sun-hee
Brinkmann, Ulrich
Application Number:
JP50217295A
Publication Date:
December 08, 2003
Filing Date:
June 14, 1994
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C12N15/02; A61K38/00; A61K39/395; A61K47/48; A61P35/00; C07K14/725; C07K16/00; C07K17/00; C12N15/09; C12P21/08; (IPC1-7): C12N15/02; A61K38/00; A61K39/395; A61P35/00; C07K14/725; C07K16/00
Domestic Patent References:
| JP3500005A |
Other References:
Ｊ．Ｉｍｍｕｎｏｌ．（１９９２）Ｖｏｌ．１４９，Ｎｏ．１，ｐ．１２０−１２６
Attorney, Agent or Firm:
Takashi Ishida (2 outside)