Title:
【発明の名称】ヒト神経膠腫のEGF受容体遺伝子の構造変化
Document Type and Number:
Japanese Patent JP2975679
Kind Code:
B2
Abstract:
The epidermal growth factor receptor (EGFR) gene is amplified in 40% of malignant gliomas and the amplified genes are frequently rearranged. The genetic alterations associated with these rearrangements are characterized in five malignant gliomas. In one tumor, the rearrangement resulted in the deletion of most of the extracytoplasmic domain of the receptor, resulting in a hybrid mRNA between new sequences and the truncated EGFR. The predicted amino acid sequence of the protein from this tumor was remarkably similar to that described for several viral erb-B oncogenes. Four other tumors were noted to have internal deletions of the EGF receptor gene. These rearrangements brought about in-frame deletions affecting either of two cysteine-rich domains in the extracytoplasmic portion of the molecule. The clonal nature of these alterations, and the fact that identical alterations were seen in more than one tumor, suggests a role for these mutant receptor proteins in tumorigenesis. Furthermore, these studies document the existence of tumor specific cell molecules resulting from somatic mutation.
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Inventors:
BOOGERUSUTEIN BAATO
BIGUNAA DARERU
BIGUNAA DARERU
Application Number:
JP51431490A
Publication Date:
November 10, 1999
Filing Date:
August 15, 1990
Export Citation:
Assignee:
JOONZU HOPUKINZU UNIV ZA
DEYUUKU UNIV
DEYUUKU UNIV
International Classes:
A61K45/00; A61K47/48; A61K49/00; A61K51/10; A61P35/00; C07K7/06; A61K39/395; C07K7/08; C07K14/71; C07K16/00; C07K16/28; C12N1/21; C12N5/10; C12N15/02; C12N15/09; C12N15/12; C12P21/02; C12P21/08; C12Q1/68; G01N33/53; G01N33/574; G01N33/577; A61K38/00; (IPC1-7): C12N15/09; C07K14/71; C07K16/28; C12N5/10; C12P21/08
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)