Title:
【発明の名称】エストロゲンレセプターモジュレーターとしての置換イソオキサゾール
Document Type and Number:
Japanese Patent JP2002522425
Kind Code:
A
Abstract:
Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
Inventors:
Huebner, Berena Dee.
Lynn, Xiao Dong
James, ian
Chain, rear
Desai, Manoji
Moore, Jennifer C.
Cryult, beata
Navarranham, Sayaran
Shin, Razinder
Trainer, Rob
Wang, Liang
Lynn, Xiao Dong
James, ian
Chain, rear
Desai, Manoji
Moore, Jennifer C.
Cryult, beata
Navarranham, Sayaran
Shin, Razinder
Trainer, Rob
Wang, Liang
Application Number:
JP2000563634A
Publication Date:
July 23, 2002
Filing Date:
August 06, 1999
Export Citation:
Assignee:
Chiron Corporation
International Classes:
A61K31/42; A61K31/422; A61K31/423; A61K31/424; A61K31/4433; A61K31/4439; A61K31/454; A61K31/4745; A61P5/30; A61P19/10; A61P25/28; A61P43/00; C07D261/08; C07D261/10; C07D261/18; C07D261/20; C07D409/04; C07D413/04; C07D413/12; C07D498/04; (IPC1-7): C07D261/08; A61K31/4745; A61P5/30; A61P19/10; A61P25/28; A61P43/00; C07D261/18; C07D261/20; C07D409/04; C07D413/12; C07D498/04
Domestic Patent References:
| JPH09291082A | 1997-11-11 |
Foreign References:
| WO1997034881A1 | 1997-09-25 |
Attorney, Agent or Firm:
Shusaku Yamamoto