Title:
【発明の名称】ジドブジン、1592U89および3TCまたはFTCの相乗的組み合わせ
Document Type and Number:
Japanese Patent JP2954357
Kind Code:
B2
Abstract:
The present invention relates to therapeutic combinations of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol (1592U89), 3'-azido-3'-deoxythymidine (zidovudine) and (2R,cis)-4-amino-]-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (3TC) (or, alternatively to 3TC, (2R,cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (FTC)) which have anti-HIV activity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HIV infections including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.
Inventors:
BERII DEIBITSUDO UORUTAA
SENTO KUREAA MAASA HAIDAA
SENTO KUREAA MAASA HAIDAA
Application Number:
JP52893196A
Publication Date:
September 27, 1999
Filing Date:
March 28, 1996
Export Citation:
Assignee:
UERUKAMU FUAUNDEESHON LTD ZA
International Classes:
A61K31/00; A61K31/165; A61K31/505; A61K31/33; A61K31/39; A61K31/44; A61K31/513; A61K31/52; A61K31/55; A61K31/70; A61K31/706; A61K31/7072; A61K31/7076; A61P31/00; A61P31/12; A61P31/18; A61P37/04; A61P43/00; C07D411/04; C07D473/16; C07H19/073; A61K; A61P; (IPC1-7): A61K31/505; A61K31/00; A61K31/52
Domestic Patent References:
| JP245486A | ||||
| JP6234641A |
Other References:
【文献】国際公開92/15309(WO,A1)
【文献】国際公開93/23021(WO,A1)
【文献】欧州公開1513917(EP,A1)
【文献】Program Abstracts of Intevscience Conference of Antimicrobial Agents and Chemotherapy,(1994),P.92,7
【文献】Scrip World Pharmacentical News,No.1969,(1994),P.26
【文献】国際公開93/23021(WO,A1)
【文献】欧州公開1513917(EP,A1)
【文献】Program Abstracts of Intevscience Conference of Antimicrobial Agents and Chemotherapy,(1994),P.92,7
【文献】Scrip World Pharmacentical News,No.1969,(1994),P.26
Attorney, Agent or Firm:
Kazuo Sato (2 outside)