Title:
【発明の名称】細胞接着を促進または阻害し、ガン細胞転移を阻害し、そしてアポトーシスを誘導する合成グリコアミン
Document Type and Number:
Japanese Patent JP2001506604
Kind Code:
A
Abstract:
A class of molecules and methods that alter cell adhesion, inhibit cancer metastasis, and induce apoptosis. A method according to the present invention comprises bringing cells into contact with compounds that essentially consist of an amino acid linked to a carbohydrate wherein the amino acid and the carbohydrate are linked to form a compound chosen from the group consisting of Schiff bases, N-glycosides, esters, and Amadori products. The carbohydrate is preferably a monosaccharide or a small oligosaccharide. The carbohydrate and amino acid sub-units may be chemically modified. For example, the amino acid may be modified by covalently bonding other groups to the amino group, carboxyl group, or side chain group of the amino acid. The carbohydrate sub-unit is preferably a pentose such as arabinose, xylose, ribose, ribulose, a hexose such as fructose, deoxyfructose, galactose, glucose, mannose, tagatose, rhamnose, or a disaccharide based on two of the above such as maltose, lactose, maltulose, or lactulose.
More Like This:
Inventors:
Grinsky, Nguyen Nadi Buoy.
Application Number:
JP52482098A
Publication Date:
May 22, 2001
Filing Date:
November 24, 1997
Export Citation:
Assignee:
Grinsky, Nguyen Nadi Buoy.
International Classes:
A61K38/00; A61K31/70; A61K31/7056; A61P35/00; A61P43/00; C07G3/00; C07H7/02; C07H13/04; C07H15/04; C07H15/12; C07K5/00; C12N9/00; (IPC1-7): A61K38/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Previous Patent: 抗―Xa活性を有する化合物及び血小板凝集拮抗剤化合物を含有する製薬...
Next Patent: 2―アミノ―2―イミダゾリン、グアニジン、および2―アミノ―3,4...
Next Patent: 2―アミノ―2―イミダゾリン、グアニジン、および2―アミノ―3,4...