DETECTABLE MOLECULE, MANUFACTURE AND USE

Title:

DETECTABLE MOLECULE, MANUFACTURE AND USE

Document Type and Number:

Japanese Patent JPS60197645

Kind Code:

A

Abstract:

A detectable molecule of the formulawhere A³ is A² or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyi, carbonyl, carboxy, thiol or a residue comprising an activated carbon; -X- is selected from the group consisting ofa C₁-C₁₀ branched or unbranched alkyl or aralkyl, which may be substituted by -OH; -Y- is a direct bond to -E-, or -Y- is -E-R²- where R² is a C₁-C₁₀ branched or unbranched alkyl; Z_a is chlorine, bromine or iodine; E is 0, NH or an acyclic divalent sulfur atom; Det^b is a chemical moiety capable of being detected, preferably comprising biotin or a metal chelator of the formula:or the 4-hydroxy or acyloxy derivative thereof, where R³ is C₁-C₄ alkyl or CH₂COOM, M is the same or different and selected from the group consisting of hydrogen, a metal or non-metal cation or is C,-C,_o alkyl, aryl or aralkyl; and m is an integer from 1 to the total number of modified reactive groups on A³. The detectable molecules are useful in in vitro or in vivo assays or therapy.

Inventors:

JIYANISU SUTABURIANOPOROSU

Application Number:

JP1463685A

Publication Date:

October 07, 1985

Filing Date:

January 30, 1985

Export Citation:

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Assignee:

ENZO BIOCHEM INC

International Classes:

A61K39/00; A61K39/395; A61K51/00; A61K51/04; A61K51/10; B01J45/00; C07C67/00; C07C227/00; C07C227/16; C07C229/16; C07C231/00; C07C233/01; C07C233/64; C07C245/02; C07C245/24; C07C251/02; C07C271/06; C07C309/63; C07C311/01; C07C311/15; C08F8/00; C07C313/00; C07C323/30; C07C323/35; C07C323/43; C07C323/48; C07C323/60; C07F9/09; C07F9/655; C07H19/067; C07H19/073; C07H19/167; C07H19/173; C07K1/113; C07K1/13; C07K14/00; C07K14/575; C07K14/76; C07K14/765; C07K16/00; C07K16/26; C08B37/02; C08G85/00; G01N33/532; G01N33/533; G01N33/534; G01N33/553; G01N33/58; (IPC1-7): A61K39/00; A61K39/395; A61K43/00; A61K49/02; B01J45/00; C07C101/14; C07C103/127; C07C149/26; C07C149/42; C07F9/09; C07H19/067; C07H19/073; C07H19/167; C07H19/173; C07K15/12; C08B37/02; C08F8/00; C08G85/00; G01N33/532; G01N33/58

Attorney, Agent or Firm:

Haruo Hamada

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