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Patent Searching and Data


Title:
認知症の検出および治療
Document Type and Number:
Japanese Patent JP2009538631
Kind Code:
A
Abstract:
This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Inventors:
Hutton Michael El.
Baker Matthew Colin
Gas jennifer mae
Raidmakers Rosa
Eriksen Jason
Pickering-Brown Stuart M.
Mackenzie Ian Raid Alexander
Feldman Howard
Kumar-Shin Samia
Bambro Ekhoven Christine
Kratz Mark
Application Number:
JP2009513441A
Publication Date:
November 12, 2009
Filing Date:
May 30, 2007
Export Citation:
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Assignee:
Mayo Foundation for Medical Education and Research
THE UNIVERSITY OF MANCHESTER
University of British Columbia
VIB VZW
University Antwerp
International Classes:
C12N15/09; A61K31/192; A61K31/196; A61K31/216; A61K31/405; A61K31/426; A61K31/616; A61K31/711; A61K35/76; A61K38/00; A61K48/00; A61P25/00; A61P25/14; A61P25/28; A61P43/00; C12Q1/02; C12Q1/68; G01N33/50; G01N33/68; C07D209/28; C07D277/20; C07D277/34
Foreign References:
US20050069881A12005-03-31
US20050123962A12005-06-09
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki