Title:
Detection and a therapeutic method based on the prostatic cancer specific changes in ERG gene expression, and those change
Document Type and Number:
Japanese Patent JP6078484
Kind Code:
B2
Abstract:
The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA / KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG.
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Inventors:
Srivastava, Shiv
Dovi, Albert
Threenas, Tador
Petrovics, George
Sun, Chen
Dovi, Albert
Threenas, Tador
Petrovics, George
Sun, Chen
Application Number:
JP2014018284A
Publication Date:
February 08, 2017
Filing Date:
February 03, 2014
Export Citation:
Assignee:
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Incorporated
International Classes:
C12N15/09; A61K31/7088; A61K48/00; A61P13/08; A61P35/00; C07K14/47; C12N15/113; C12Q1/68
Foreign References:
| WO2005113816A1 |
Other References:
Gene,2004年,Vol.324,P.65-77
Oncogene,2005年,Vol.24,P.3847-3852
Oncogene,2005年,Vol.24,P.3847-3852
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Yumi Naito
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Yumi Naito
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