PURPOSE: To readily obtain biological particles by mixing the biological particles with a receptor and keeping the contact of the biological particles with the receptor for a sufficient time to allow the biological particles to bind on the surface of the specific receptor.

CONSTITUTION: Target cells 20 such as blood, etc. are introduced into a separating vessel 10, and a supernatant 12 is obtained by removing erythrocyte cells, etc. therefrom. The supernatant 12 is supplied to a centrifugal separator having tubes 14, and subjected to centrifugation and concentration to provide the objective cells 20 in tubes 16. The cells 20 are introduced into a supplying vessel 22 and supplied through a valve 24 to a cell-capturing device 26 comprising a polystyrene vessel, etc. having receptors 34 (R) arranged on sheets 30 separated by supporters 32 and formed out of a polystyrene film, etc. The cells are supplied through a duct 36 to the device 26 to precipitate the cells, and further to precipitate the cells at the reverse side by reversing the device 26. A washing is introduced from a duct 36 to the device 26, and discharged from the duct 40 to remove non-binding cells. Thereafter, the captured and bound cells are confirmed by adding a medium containing an interleukin, etc. or recovered by separating the device 26, putting the device in an ultrasonic vessel to allow the cells to be released and recovering the released cells.