To obtain a new compound, in particular exhibiting a protein kinase C isozyme β selectively inhibiting function, and useful for treatment and prevention of diabetic complications or the like, e.g. diabetic retinopathy.
This compound is shown by formula I [R1 is H or a lower alkyl; R2 is a (substituted) aryl or the like; R3 and R5 to R8 are each H, a halogen or the like; R4 forms a compound shown by formula II or the like together with W or R3, and a compound shown by formula III together with R5; W is shown by the formula (CH2)l-(Y)m-(CH2)n-Z; Y is O, S or the like; Z is H, a halogen or the like; (l), (n), (p), (q) and (r) are each 0 to 4; (m) is 0 or 1; W' is H or the like; and the * side is bound to the indole nitrogen], preferably 3-(1H-indol-3-yl)4-[(3-methoxyphenyl)amino]-1H-pyrrole-2,5-dione or the like. The compound shown by formula I is obtained by, e.g. reacting a compound shown by formula IV with an oxalic ester (e.g. dimethyl oxalate) for condensation/cyclization, and reacting the product compound with a compound shown by the formula: NHR1R2.
TANAKA MASAHIRO
SAKOTA KENJI
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