NEW MATERIAL: The compound of formula [A is H, 1-6C alkyl or the like; B and D are each formula II, III (R12 is H, 1-5C alkyl or the like; R2 is 1-7C alkyl, H or the like) or the like; R1 is H, 3-6C alkyl or the like; X is formula IV or V (R13 or R14 are H, 2-7C alkenyl or the like); E is H, aryl, alkenyl or the like] and its salt.
USE: Antihypertensive agents, remedies of hyperaldosteronism, etc. Having high oral bioavailability and long acting duration.
PROCESS: For example, BOC-protected amino alcohol derivative is obtained by using N-tert-butyloxylcarbonyl-cyclohexylaranyl, etc., after enolate of 2- pyrrolidinone is prepared by allowing a 2-pyrrolidinone derivative to react in the presence of a base such as lithiumisopropylamide, etc. The compound of formula I is obtained by allowing BOC-protected amino alcohol derivative to bond to an amino acid according to a method of synthesis of a peptide after an N protective group is eliminated and again eliminating a protective group.
| JP2002355077 | CASPASE 3 INHIBITOR |
| WO/1994/025581 | MODIFIED RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR |
DANIERU EFU BUEEBAA
UIRIAMU JIEE GURIINRII
JIYAN TEN BUREEKE
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