Title:
Diagnosis and medical treatment of multiplex Sulfatase deficiency and other Sulfatase deficiency
Document Type and Number:
Japanese Patent JP6007203
Kind Code:
B2
Abstract:
This invention relates to methods and compositions for the diagnosis and treatment of Multiple Sulfatase Deficiency (MSD) as well as other sulfatase deficiencies. More specifically, the invention relates to isolated molecules that modulate post-translational modifications on sulfatases. Such modifications are essential for proper sulfatase function.
Inventors:
Phone figurine cart
Schmid Bernhard
Darks Thomas
Hartrain Michael W.
Baravio Andrea
Kozuma Maria Pier
Schmid Bernhard
Darks Thomas
Hartrain Michael W.
Baravio Andrea
Kozuma Maria Pier
Application Number:
JP2014036642A
Publication Date:
October 12, 2016
Filing Date:
February 27, 2014
Export Citation:
Assignee:
Shire Human Genetic Therapy Inc.
International Classes:
C12N15/09; A61K38/44; A61P43/00; C12N9/02; C12N9/66; A61K38/00
Domestic Patent References:
| JP5241101B2 | ||||
| JP5527854B2 |
Foreign References:
| WO2002098455A1 | ||||
| US6153188 | ||||
| US20020106358 | ||||
| WO2001060991A1 | ||||
| WO2000050443A1 |
Other References:
Cell,Vol.82,No.2(1995)p.271-278
Chem.Biol.,Vol.5,No.8(1998)p.R181-R186
DIERKS, T. et al.,"Conversion of cysteine to formylglycine in eukaryotic sulfatases occurs by a common mechanism in the endoplasmic reticulum.",FEBS LETT.,1998年 2月13日,No.423, No.1,P.61-65
VON FIGURA, K. et al.,"A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease.",BIOESSAYS,1998年 6月,Vol.20, No.6,P.505-510
Biochem.J.,Vol.311,Pt.1(1995)p.333-339
Biochem.Biophys.Res.Commun.,Vol.181,No.2(1991)p.677-683
Eur.J.Hum.Genet,Vol.10,No.12(2002)p.813-818
J.Biol.Chem.,Vol.277,No.51(2002)p.49175-49185
Chem.Biol.,Vol.5,No.8(1998)p.R181-R186
DIERKS, T. et al.,"Conversion of cysteine to formylglycine in eukaryotic sulfatases occurs by a common mechanism in the endoplasmic reticulum.",FEBS LETT.,1998年 2月13日,No.423, No.1,P.61-65
VON FIGURA, K. et al.,"A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease.",BIOESSAYS,1998年 6月,Vol.20, No.6,P.505-510
Biochem.J.,Vol.311,Pt.1(1995)p.333-339
Biochem.Biophys.Res.Commun.,Vol.181,No.2(1991)p.677-683
Eur.J.Hum.Genet,Vol.10,No.12(2002)p.813-818
J.Biol.Chem.,Vol.277,No.51(2002)p.49175-49185
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi
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