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Title:
診断及び治療用エピトープ並びにトランスジェニック植物
Document Type and Number:
Japanese Patent JP5371890
Kind Code:
B2
Abstract:
A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope comprising sequence which is: SEQ ID NO: 1 or 2, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID N0:3, (ii) an epitope comprising sequence comprising: SEQ ID NO:1, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO:3, which epitope is an isolated oligopeptide derived from a gliadin protein, (iii) an analogue of (i) or (ii) which is capable of being recognised by a T cell receptor that recognises (i) or (ii), which in the case of a peptide analogue is not more than 50 amino acids in length, or (iv) a product comprising two or more agents as defined in (i), (ii) or (iii), and (b) determining in vitro whether T cells in the sample recognise the agent; recognition by the T cells indicating that the individual has, or is susceptible to, coeliac disease. Therapeutic compositions which comprise the epitope and gliadin proteins which do not cause coeliac disease are also provided.

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Inventors:
Anderson, Robert, Paul
Hill, adrian, vivian, synthon
Jewel, Derek, Parry
Application Number:
JP2010135844A
Publication Date:
December 18, 2013
Filing Date:
June 15, 2010
Export Citation:
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Assignee:
Isis Innovation Limited
International Classes:
A01H5/00; C12N15/09; A01H1/00; A01H5/10; A01K67/027; A23L1/305; A61K39/00; A61K45/00; A61P37/06; A61P37/08; A61P43/00; C07K14/415; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/82; G01N33/15; G01N33/50; G01N33/53; G01N33/564
Other References:
Aliment Pharmacol Ther. 1999 Jul;13(7):945-50.
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10050-4.
Bioorg Med Chem Lett. 1998 Aug 4;8(15):2039-44.
UHLIG H,AUTOIMMUNITY,1998年,V28 N4,P185-195
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka



 
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