Title:
ヒトHIF3alpha遺伝子およびタンパク質の神経変性疾患に関する診断的および治療的用途
Document Type and Number:
Japanese Patent JP2007519399
Kind Code:
A
Abstract:
The present invention discloses the differential expression of a gene coding for HIF3a in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating a neurodegen-erative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the HIF3a gene and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
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Inventors:
Von der Kammer Heinz
Paulner Yoharness
Paulner Yoharness
Application Number:
JP2006544454A
Publication Date:
July 19, 2007
Filing Date:
December 17, 2004
Export Citation:
Assignee:
Evotech Neuroscience Gesell Shaft Mitt Beschlenktel Haftung
International Classes:
C12Q1/68; A01K67/027; A01K67/033; A61K35/76; A61K38/00; A61K45/00; A61K48/00; A61K49/00; A61P3/04; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07K14/47; C07K14/705; C12N15/85; C12Q1/02; G01N33/15; G01N33/48; G01N33/50; G01N33/53; G01N33/68; C12N15/09
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes