Title:
LFA-1アンタゴニストとして有用なジアザシクロアルカンジオン誘導体
Document Type and Number:
Japanese Patent JP4189216
Kind Code:
B2
Abstract:
Compounds of formula Iwherein R is carboxy, esterified carboxy or amidated carboxy;R1 and R3 are independently lower alkyl, (hydroxy, lower alkoxy, amino, acylamino, mono- or di-lower alkylamino or mercapto)-lower alkyl, lower alkyl-(thio, sulfinyl or sulfonyl)-lower alkyl, cycloalkyl, aryl, biaryl, (cycloalkyl, aryl or biaryl)-lower alkyl, or (carboxy, esterified carboxy or amidated carboxy)-lower alkyl;R2 is hydrogen, lower alkyl, cycloalkyl, aryl, biaryl, arylaminocarbonyl, or aryl-(oxy, thio or amino);n is 1 or 2;Y is lower-alkylene or lower alkenylene;and pharmaceutically acceptable salts thereof; which are useful as LFA-1 antagonists.
Inventors:
Liner Albert
Janet Dawson King
Klaus Eahart
Sompong Wattanashin
Gabriele Bites Schmidt
Karl Berzenbach
Janet Dawson King
Klaus Eahart
Sompong Wattanashin
Gabriele Bites Schmidt
Karl Berzenbach
Application Number:
JP2002532428A
Publication Date:
December 03, 2008
Filing Date:
October 01, 2001
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07D241/08; A61K31/495; A61K31/496; A61K31/4965; A61K31/551; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07D243/08; C07D401/06; C07D401/10; C07D401/12
Domestic Patent References:
| JP2002544187A | ||||
| JP2000178258A |
Foreign References:
| WO2001027102A1 | ||||
| WO1996032385A1 | ||||
| WO1998039303A1 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
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